Acute atomoxetine treatment of younger and older children with ADHD: A meta-analysis of tolerability and efficacy

Table 3 Summary of Treatment-Emergent Adverse Events Reported by at Least 5% of Subjects in Either Age Group

	6- and 7-Year Olds			8- to 12-Year Olds
	ATX	PBO		ATX	PBO
	N = 183	N = 95		N = 542	N = 316
Event	n (%)	(n) %	p Value^a	(n) %	(n) %	p Value^a	p Value^b
Abdominal pain upper	34 (18.6)	6 (6.3)	.006	83 (15.3)	40 (12.7)	.313	.044
Decreased appetite	30 (16.4)	3 (3.2)	< .001	82 (15.1)	17 (5.4)	< .001	.331
Headache	25 (13.7)	8 (8.4)	.243	90 (16.6)	54 (17.1)	.850	.214
Vomiting	25 (13.7)	2 (2.1)	.001	51 (9.4)	18 (5.7)	.068	.053
Cough	18 (9.8)	6 (6.3)	.375	18 (3.3)	28 (8.9)	< .001	.007
Nausea	13 (7.1)	2 (2.1)	.097	42 (7.7)	20 (6.3)	.496	.186
Fatigue	12 (6.6)	2 (2.1)	.150	39 (7.2)	8 (2.5)	.003	.918
Somnolence	12 (6.6)	1 (1.1)	.040	50 (9.2)	14 (4.4)	.010	.294
Irritability	9 (4.9)	2 (2.1)	.342	33 (6.1)	9 (2.8)	.034	.924
Pyrexia	9 (4.9)	2 (2.1)	.342	15 (2.8)	17 (5.4)	.062	.058
Nasopharyngitis	8 (4.4)	4 (4.2)	1.00	26 (4.8)	24 (7.6)	.098	.442
Upper respiratory tract infection	8 (4.4)	3 (3.2)	.754	16 (3.0)	17 (5.4)	.096	.206
Pharyngolaryngeal pain	2 (1.1)	3 (3.2)	.342	26 (4.8)	29 (9.2)	.014	.687

Abbreviations: ATX = atomoxetine; N, n = number; PBO = placebo.
^aP values comparing ATX and PBO within each subgroup are based on Fisher's exact test.
^bP values comparing odds ratios between children and adolescent

ISSN: 1753-2000