Table 3 Trends for different types of antipsychotic prescriptions and off-label usage
Drugs | Total(n = 48,258) | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | Common diagnoses | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N1 (%)a | Off-label N2 (%)b | N1(%) | Off-label N2 (%) | N1 (%) | Off-label N2 (%) | N1(%) | off-label N2(%) | N1(%) | off-label N2(%) | N1(%) | off-label N2(%) | N1(%) | off-label N2(%) | |||
Typical | Haloperidol | 2444(5.1) | 373(15.3) | 490(1.0) | 82(16.7) | 488(1.0) | 88(18.0) | 477(0.99) | 88(18.5) | 464(0.96) | 63(13.6) | 265(0.55) | 20(7.5) | 260(0.54) | 32(12.3) | Tic disorder, epilepsy, schizophrenia |
Sulpiride | 962(2.0) | 625(65.0) | 179(0.37) | 129(72.1) | 191(0.40) | 125(65.3) | 241(0.50) | 154(63.9) | 311(0.64) | 203(65.4) | 15(0.031) | 11(73.3) | 25(0.052) | 3(12.0) | Mood disorder, schizophrenia, depressive state | |
Tiapride | 7631(15.8) | 519(6.8) | 1062(2.2) | 76(7.2) | 1336(2.8) | 109(8.2) | 1636(3.4) | 127(7.8) | 1498(3.1) | 83(5.5) | 1068(2.2) | 57(5.3) | 1031(2.1) | 67(6.5) | Tic disorder | |
Chlorpromazine | 3907(8.1) | 3774(96.6) | 992(2.1) | 971(97.9) | 859(1.8) | 820(95.5) | 628(1.3) | 605(96.3) | 1034(2.1) | 1005(97.2) | 221(0.46) | 212(95.9) | 173(0.36) | 161(93.1) | Upper respiratory tract infection, autism, epilepsy | |
Atypical | Aripiprazole | 8965(18.6) | 7317(81.6) | 923(1.9) | 717(77.7) | 1055(2.2) | 804(76.2) | 1242(2.6) | 909(73.2) | 1553(3.2) | 1219(78.5) | 1761(3.6) | 1507(85.6) | 2431(5.0) | 2161(88.9) | Schizophrenia, depressive state, Tic disorder, mental disorders |
Amisulpride | 901(1.9) | 525(58.3) | 64(0.13) | 23(35.9) | 123(0.25) | 59(48.0) | 134(0.28) | 68(50.7) | 178(0.37) | 98(55.1) | 173(0.36) | 114(65.9) | 229(0.47) | 163(71.2) | Schizophrenia, mental disorders | |
Olanzapine | 8787(18.2) | 6229(70.9) | 1029(2.1) | 693(67.3) | 1182(2.4) | 823(69.6) | 1369(2.8) | 867(63.3) | 1836(3.8) | 1205(65.6) | 1627(3.4) | 1233(75.8) | 1744(3.6) | 1408(80.7) | Schizophrenia、depressive state, mental disorders | |
Quetiapine | 8952(18.6) | 6442(72.0) | 475(0.98) | 268(56.4) | 535(1.1) | 321(60.0) | 817(1.7) | 535(65.5) | 1583(3.3) | 1131(71.4) | 2213(4.6) | 1591(71.9) | 3329(6.9) | 2596(78.0) | Depressive state, bipolar disorder, Mood disorder | |
Risperidone | 8346(17.3) | 4634(55.5) | 1107(2.3) | 548(49.5) | 1232(2.6) | 602(48.9) | 1315(2.7) | 636(48.4) | 1659(3.4) | 830(50.0) | 1374(2.8) | 858(62.4) | 1659(3.4) | 1160(69.9) | Schizophrenia、mental disorders, autism | |
Clozapine | 1095(2.3) | 549(50.1) | 213(0.44) | 132(62.0) | 161(0.33) | 73(45.3) | 160(0.33) | 71(44.3) | 172(0.36) | 81(47.0) | 162(0.34) | 76(46.9) | 227(0.47) | 116(51.1) | Schizophrenia, mental disorders, bipolar disorder | |
Paliperidone | 1252(2.6) | 876(69.9) | 112(0.26) | 78(69.6) | 149(0.31) | 94(63.0) | 155(0.32) | 75(48.3) | 181(0.38) | 118(65.1) | 273(0.57) | 203(74.3) | 382(0.79) | 308(80.6) | Schizophrenia, mental disorders, bipolar disorder | |