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Table 2 Comparison of the levels of serum 5-HT between children with ASD and TD

From: Gender specific influence of serotonin on core symptoms and neurodevelopment of autism spectrum disorders: A multicenter study in China

Group total

5-HT, Median (IQR)

Wald chi-square

P-value

TD (n = 1270)

132.00 (99.75–170.00)

12.108

0.001

ASD (n = 1387)

136.00 (97.00–180.00)

Boys

TD (n = 832)

134.00 (103.00–173.75)

7.494

0.006

ASD (n = 1137)

137.00 (99.00–182.00)

Girls

TD (n = 438)

126.00 (91.00–166.00)

0.566

0.452

ASD (n = 250)

128.00 (91.75–167.50)

Gender

Boys with ASD (n = 1137)

137.00 (99.00–182.00)

8.076

0.004

Girls with ASD (n = 250)

128.00 (91.75–167.50)

  1. Generalized linear models (GLM) with gamma regression were employed to compare the serum 5-HT levels between the two groups, with age as covariate
  2. TD typically developing, ASD autism spectrum disorder, IQR interquartile range