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Table 3 Comparison of the levels of serum 5-HT in children with ASD of different symptom severity

From: Gender specific influence of serotonin on core symptoms and neurodevelopment of autism spectrum disorders: A multicenter study in China

Group

5-HT, Median (IQR)

Wald chi-square

P-value

Total

Mild-moderate ASD (n = 829)

135.00 (97.00–179.00)

8.831

0.003

Severe ASD (n = 349)

142.00 (103.00–199.5)

Boys

Mild-moderate ASD (n = 685)

136.00 (97.00–180.50)

9.674

0.002

Severe ASD (n = 290)

145.00 (106.25–205.25)

Girls

Mild-moderate ASD (n = 144)

127.00 (98.00–174.25)

0.037

0.847

Severe ASD (n = 59)

130.00 (92.00–161.00)

  1. Generalized linear models (GLM) with gamma regression were employed to compare the serum 5-HT levels between the two groups, with age as covariate
  2. ASD autism spectrum disorder, IQR interquartile range