Gender specific influence of serotonin on core symptoms and neurodevelopment of autism spectrum disorders: A multicenter study in China

Table 4 Correlations of serum 5-HT levels on the scores of SRS, CARS and communication warning behavior of CNBS-R2016 in the ASD children at different sex groups

Behavior subscales	Total		Boys		Girls
Behavior subscales	β (95% CI)	P	β (95% CI)	P	β (95% CI)	P
SRS scale scores	n = 1177		n = 966		n = 211
Social awareness	1.822 (0.691 to 2.953)	0.002	2.080 (0.814 to 3.345)	0.001	0.888 (− 1.579 to 3.355)	0.479
Social cognition	1.095 (0.274 to 1.916)	0.009	1.188 (0.276 to 2.099)	0.011	0.700 (− 1.159 to 2.559)	0.459
Social communication	0.374 (− 0.046 to 0.795)	0.081	0.511 (0.039 to 0.983)	0.034	− 0.176 (− 1.081 to 0.728)	0.701
Social motivation	0.576 (− 0.169 to 1.321)	0.130	0.889 (0.054 to 1.725)	0.037	− 0.724 (− 2.328 to 0.881)	0.375
Autistic mannerisms	0.668 (0.036 to 1.301)	0.038	0.686 (− 0.020 to 1.392)	0.057	0.484 (− 0.914 to 1.883)	0.496
Total score	0.211 (0.047 to 0.375)	0.012	0.257 (0.074 to 0.440)	0.006	0.013 (− 0.347 to 0.373)	0.944
CARS scale scores	n = 1178		n = 975		n = 203
Total score	1.110 (0.561 to 1.659)	<0.001	0.290 (0.660 to 1.920)	<0.001	0.331 (− 0.737 to 1.399)	0.542
Communication Warning Behavior	n = 982		n = 801		n = 181
Communication Warning Behavior	0.311 (0.112 to 0.510)	0.002	0.389 (0.164 to 0.613)	0.001	− 0.004 (− 0.415 to 0.407)	0.984

Multivariate Linear Regression Models was employed to analyze the association between serum 5-HT level and scores of scales, with age as covariate
SRS Social Responsiveness Scale, CARS Childhood Autism Rating Scale, CNBS-R2016 Children Neuropsychological and Behavior Scale-Revision 2016, ASD autism spectrum disorder, β (95%CI) regression coefficient (95% confidence interval)

ISSN: 1753-2000