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Table 5 Estimated associations between serum 5-HT levels and the scores of SRS, CARS and communication warning behavior of CNBS-R2016 in the ASD boys

From: Gender specific influence of serotonin on core symptoms and neurodevelopment of autism spectrum disorders: A multicenter study in China

Behavior subscales

Quartiles 1 (≤ 113 ng/ml)

Quartiles 2

(113–165 ng/ml)

P

Quartiles 3

(>165 ng/ml)

P

OR (95% CI)

OR (95% CI)

OR (95% CI)

SRS scale scores

Social awareness

Reference

1.060 (1.011 to 1.112)

0.016

1.075 (1.026 to 1.127)

0.003

Social cognition

Reference

1.016 (0.982 to 1.051)

0.363

1.037 (1.003 to 1.073)

0.034

Social communication

Reference

1.014 (0.997 to 1.032)

0.116

1.017 (1.000 to 1.035)

0.053

Social motivation

Reference

1.028 (0.997 to 1.061)

0.079

1.033 (1.002 to 1.066)

0.038

Autistic mannerisms

Reference

1.015 (0.989 to 1.042)

0.271

1.027 (1.001 to 1.054)

0.045

Total score

Reference

1.006 (1.000 to 1.013)

0.069

1.009 (1.002 to 1.016)

0.010

CARS scale scores

Total score

Reference

1.018 (0.995 to 1.042)

0.135

1.037 (1.014 to 1.061)

0.002

Communication Warning Behavior

Reference

1.000 (0.992 to 1.008)

0.972

1.010 (1.002 to 1.018)

0.014

  1. Multivariate logistics regression was used for were employed to analyze the association between serum 5-HT level and scores of scales, with age as covariate
  2. SRS Social Responsiveness Scale, CARS Childhood Autism Rating Scale, CNBS-R2016 Children Neuropsychological and Behavior Scale-Revision 2016, ASD autism spectrum disorder, OR odds ratio,CI confidence interval