Gender specific influence of serotonin on core symptoms and neurodevelopment of autism spectrum disorders: A multicenter study in China

Table 6 Effect of serum 5-HT levels on the scores of CNBS-R2016 in the ASD children at different sex groups

CNBS-R2016	Total(n = 992)		Boys(n = 811)		Girls(n = 181)
CNBS-R2016	β (95% CI)	P	β (95% CI)	P	β (95% CI)	P
Gross motor	− 0.301 (− 0.503 to − 0.098)	0.004	− 0.309 (− 0.540 to − 0.077)	0.009	− 0.271 (− 0.667 to 0.125)	0.178
Fine motor	− 0.210 (− 0.425 to 0.005)	0.055	− 0.243 (− 0.487 to 0.001)	0.051	− 0.111 (− 0.545 to 0.324)	0.615
Adaptive behavior	− 0.209 (− 0.411 to − 0.007)	0.043	− 0.255 (− 0.487 to − 0.023)	0.031	− 0.075 (− 0.468 to 0.319)	0.708
Language	− 0.149 (− 0.313 to 0.015)	0.074	− 0.213 (− 0.399 to − 0.027)	0.025	0.094 (− 0.241 to 0.429)	0.579
Personal-social	− 0.255 (− 0.458 to − 0.053)	0.013	− 0.285 (− 0.516 to − 0.054)	0.016	− 0.116 (− 0.516 to 0.283)	0.565
Genernal quotient	− 0.297 (− 0.523 to − 0.071)	0.010	− 0.352 (− 0.610 to − 0.094)	0.008	− 0.109 (− 0.554 to 0.336)	0.629

Univariate Logistics Regression was employed to analyze the association between serum 5-HT level and scores of CNBS-R2016 scale, with age as covariate
CNBS-R2016 Children Neuropsychological and Behavior Scale-Revision 2016, ASD autism spectrum disorder, β (95%CI) regression coefficient (95% confidence interval)

ISSN: 1753-2000